The girl was a back seat passenger in a Dodge Caravan that was hit by a Jeep Cherokee.

A six-year-old girl was killed Sunday in a three-car crash southwest of Millsboro.

Delaware State Police spokeswoman Master Cpl. Melissa Jaffe said the collision took place at 11:41 a.m. Sunday, Sept. 9.

Jaffe explained that a Jeep Cherokee was traveling eastbound on Lowes Crossing Road approaching the intersection of Millsboro Highway with a posted stop sign.

A Dodge Caravan was traveling northbound on Millsboro Highway approaching the intersection of Lowes Crossing Road and Bald Branch Road and a Dodge Ram pickup was traveling westbound on Bald Branch Road and had stopped at the stop sign at the intersection of Millsboro Highway.

Millsboro Highway is a throughway and does not stop, Jaffe said.

The crash occurred when the Cherokee failed to stop for the posted stop sign and crossed directly in front of the Caravan. The front of the Caravan struck the right side of the Cherokee, sending the Caravan to spinning off the east side of the roadway where it hit the front of the Dodge Ram. The Cherokee was also forced off the east side of the roadway into the grass.

The driver of the Cherokee, a 30-year-old woman from Frankford, who was wearing her seat belt, was taken to Nanticoke Memorial Hospital where she was treated and released with non-life threatening injuries.

Her daughter, a passenger in the second row, also was taken to Nanticoke Memorial but was pronounced dead. The girl was properly restrained as well, Jaffe said.

The Caravan’s driver, a 64-year-old man from Salisbury, Md., was taken to the Peninsula Regional Medical Center, treated and released with non-life threatening injuries. A woman passenger, also from Salisbury, was admitted to Peninsula Regional with non-life-threatening injuries.

The driver of the Dodge Ram, a 46-year-old man from Georgetown, was properly restrained and not injured.

Impairment does not appear to be a factor on behalf of any of the drivers, Jaffe said.

Millsboro Highway in the area of Lowes Crossing Road was closed for approximately three hours while the crash was investigated and cleared.